Poly-L-arginine hydrochloride, mol wt 15,000-70,000

Analysis Note

Molecular weight based on viscosity of precursor poly-L-ornithine. Also assayed by MALLS.

Application

Poly-L-arginine hydrochloride has been used:to generate complex with stimulatory RNA isRNA9.2 as in neutrophilsused in ribosomal RNA transfection into human monocytic THP-1 cellsfor coating alginate capsule beads

General description

Poly-L-arginine hydrochloride (PLA) is a homopolyamino acid. PLA enhances membrane permeability compared to poly-L-lysine. It has applications as drug carrier, neuroprotective agent and in anticancer vaccines preparations. Peptide vaccines in conjugation with PLA promotes antigen-presenting cells (APCs) to generate T cell and elicit immunostimulant functionality.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Packaging

50, 100 mg in poly bottle

10 mg in glass bottle

Quality

Contains 3% or less ornithine residue.